Korean Journal of Nephrology 2008;27(5):622-625.
A Case of Rapidly Progressive Glomerulonephritis in a Hepatitis B Virus Carrier Successfully Treated with High dose Immunosuppressive Therapy and Prophylactic Lamivudine
Jung Eun Lee, M.D.1, 3, Jung Myung Lee, M.D.1, Jung Tak Park, M.D.1, 3, Kyu Hun Choi, M.D.1, 3, Ho Yung Lee, M.D.1, 3, Dae-Suk Han, M.D.1, 3, Hyeun Joo Jeong, M.D.2, 3 and Beom Seok Kim, M.D.1, 3
Department of Internal Medicine1 and Pathology2
Institute of Kidney Disease3
Yonsei University College of Medicine, Seoul, Korea
증례 : A Case of Rapidly Progressive Glomerulonephritis in a Hepatitis B Virus Carrier Successfully Treated with High dose Immunosuppressive Therapy and Prophylactic Lamivudine
Jung Eun Lee, M.D.1, 3, Jung Myung Lee, M.D.1, Jung Tak Park, M.D.1, 3, Kyu Hun Choi, M.D.1, 3, Ho Yung Lee, M.D.1, 3, Dae-Suk Han, M.D.1, 3, Hyeun Joo Jeong, M.D.2, 3 and Beom Seok Kim, M.D.1, 3
Department of Internal Medicine1 and Pathology2, Institute of Kidney Disease3, Yonsei University College of Medicine, Seoul, Korea
Abstract
A 35-year-old man, previously hepatitis B surface antigen (HBsAg) carrier, presented with gross hematuria and heavy proteinuria that he had been suffering from for 1 month. Serum creatinine was 4.4 mg/dL. Renal biopsy showed pauci-immune crescentic glomerulonephritis. He received plasmapheresis and was treated with high-dose steroids and cyclophosphamide. Lamivudine was started for the prevention of hepatitis B virus (HBV) activation. Serum creatinine and proteinuria were ameliorated one week after the treatment. There was no sign of HBV activation after six months of treatment. We report a case of rapidly progressive glomerulonephritis in a HBV carrier successfully treated with high dose immunosuppressive therapy and prophylactic lamivudine.
Key Words: Lamivudine, Hepatitis B virus, Rapidly progressive glomerulonephritis


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